A leading pioneer in the use of adult stem cells to treat life-threatening diseases
is calling the Vatican “a very powerful and supportive ally to helping advance this
technology.”
Dr. Robert J.Hariri, founder and chief executive officer of Celgene
Cellular Therapeutics is a U.S. neurosurgeon and trauma specialist recognized for
his discovery of pluripotent stem cells (cells that can differentiate to become nearly
any cell of the body) from placenta.
Dr. Hariri spoke to Vatican Radio after
delivering a speech on his research on adult stem cells in the treatment of autoimmune
diseases at a three day Vatican sponsored conference this week entitled “Adult Stem
Cells: Science and the Future of Man and Culture.”
Recipient of the Thomas
Alva Edison Award for his discovery of placental stem cells in 2007 and for engineering
tissues and organs from stem cells in 2011, Dr. Hariri says he was first drawn to
investigate the placenta as a therapeutic source of stem cells after seeing an ultrasound
of his daughter while she was an embryo growing in the womb. He marvelled at how
the placenta developed more rapidly than the embryo and at its nutrient-giving and
protective properties.
He explains that placental cells are “one size fits
all.” They can mature into all kinds of cells without an embryo, and do not present
problems of rejection by the patient-recipient. “The placenta is nature’s perfect
graft material. It’s accepted between recipients and donors without having the two
be matched.”
Using adult stem cells obtained from human placenta, Hariri
says he and his team of researchers have had “compelling results” in the treatment
of autoimmune and inflammatory diseases.
“We’re able to down-regulate the auto-reactive
response of diseased immune system and correct things like Crohn’s Disease, Rheumatoid
Arthritis and Multiple Sclerosis. And we find this exciting enough to continue to
invest in exploring this as a potent, therapeutic use of these cells.”
And
the supplies of these stem cells are apparently limitless. Dr. Hariri told participants
at the Vatican conference that one donor can provide cells for millions of recipients.
“The placenta is an abundant resource,” that can be easily recovered when
a woman gives birth to a child he notes. “It’s readily available, it can be procured
or recovered under very rigorous or tight controls. It’s a good, high quality source
of material. From a single placenta we can mass produce, expand, manufacture those
cells into huge numbers, quantities that allow us to treat hundreds of thousands,
and potentially millions of patients."
When asked what he thinks about the
Vatican’s decision to host this week’s stem cell conference, Dr. Hariri told Vatican
Radio’s Tracey McClure: “It’s important for people to realize that the Vatican is
a powerful, powerful advocate for science and technology. It is not interfering or
impeding progress in this space and I think that the position in supporting non-embryonic
stem cells happens to be a logical one because the tools at our disposal today don’t
violate anyone’s personal, moral or ethical standards…these stem cells which can be
derived from bone marrow, adipose (fat) tissue or from placenta are readily available,
high quality, and can meet the needs of the clinical future.”
But is there
enough public support in his country, the United States, for research into adult stem
cell research? “I think there’s confusion…considerable confusion,” reflects Dr.
Hariri. “There are underlying political and media agendas which sometimes distort
the reality. Simply enough, I think that every scientist, every physician, every
politician wants to see people have access to new breakthrough medicines that change
the way diseases are treated and this is just one new tool.”
Listen to Tracey
McClure’s full interview with Dr. Hariri: